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Collagen Booster

UltraCol 200

Collagen Booster

UltraCol 200

Hello, this is Dr. Won-sang Lee, the Chief Director of Kate Clinic. Today, I would like to give you a detailed explanation of 'UltraCol 200', which many people have been showing great interest in recently.

What is UltraCol 200 ?

It is a premium collagen booster made by processing FDA-approved PDO (Polydioxanone) into micro-spheres and injecting them into the skin. Rather than providing instant volume, it stimulates the skin to naturally produce collagen, resulting in natural volume and elasticity.

How does it work?

The mechanism of UltraCol 200

Many of my patients say, “Doctor, I’m worried fillers might look unnatural,” and UltraCol 200 is the perfect solution to that concern.

Hello, this is Dr. Won-sang Lee, the Chief Director of Kate Clinic.
Today, I would like to give you a detailed explanation of 'UltraCol 200',
which many people have been showing great interest in recently.

What is UltraCol 200 ?

It is a premium collagen booster made by processing FDA-approved PDO (Polydioxanone)
into micro-spheres and injecting them into the skin.
Rather than providing instant volume, it stimulates the skin to naturally produce collagen, resulting in natural volume and elasticity.

How does it work?

The mechanism of UltraCol 200

Many of my patients say, “Doctor, I’m worried fillers might look unnatural,” and UltraCol 200 is the perfect solution to that concern.

1
Even penetration
into the dermis

PDO micro-spheres (50–110μm in size) are evenly distributed throughout the dermal layer.

2
Collagen-stimulating
micro-stimulation

These micro-spheres gently stimulate the surrounding tissue, naturally promoting collagen production.

3
Only your own
collagen remains

After 4–12 weeks, the PDO component fully dissolves, leaving only your natural self-produced collagen.

 UltraCol 200 
Individualized solutions for 3 different types

Before going into a detailed explanation of UltraCol, let’s first discuss the treatment methods and effects of UltraCol 200 for each case type.

  Case 01  


For those concerned about
under-eye hollowness
and dark circles
case image
 Treatment method
  • Using a blunt cannula (rounded tip),
    the under-eye area is approached gently, and the “micro-droplet” technique is used to inject very small amounts across
    multiple points.
  • This minimizes the risk of vascular injury
    and significantly reduces swelling or
    bruising. Typically, 2 sessions at 2–3 week intervals are ideal.
 How Each Technology Works
  • The under-eye area has extremely thin
    and delicate skin.
  • The micro PDO spheres in UltraCol 200
    settle in this area and precisely stimulate collagen production.
  • It also improves microcirculation,
    helping reduce pigmentation and
    capillary translucency —
    the major causes of dark circles.
Treatment effects
Strengthens support in the under-eye area
to improve hollowness and enhances
microvascular circulation to reduce dark
circles. It also thickens the dermal layer,
masking visible blood vessels and softening
the overall expression around the eyes with
a natural filling effect.
  Case 02  


 For those who want
natural volume
in hollow areas
case image
 Treatment method
  • The “dual layering” technique is used to
    inject different densities into the deep
    and mid layers.
  • Focus is placed on areas that need volume, such as the temples, mid-cheek area,
    and infrazygomatic region.
  • For full-volume restoration, 3 sessions
    at 1-month intervals are recommended.
 How Each Technology Works
  • UltraCol 200 does not create instant
    volume — it builds your own natural
    volume from within.
  • PDO micro-spheres stimulate gradual
    collagen production in the deeper dermis, creating volume that forms internally.
  • This is similar to "bread dough
    rising naturally."
Treatment effects
Creates natural volume without excessiv
swelling, improves facial contour balanc
and restores sunken cheeks or temples
naturally. The results become even more
natural and refined over time.
  Case 03  


 For those hesitant abou
fillers due to
safety concerns
case image
 Treatment method
  • A blunt-tipped cannula is used to safely
    approach the area and inject only into
    the precise intended layer while avoiding
    vascular-dense regions.
 How Each Technology Works
  • The PDO component of UltraCol 200 is
    a proven material that has been used for
    over 30 years as medical sutures.
  • It is a fully biodegradable substance that
    completely dissolves within 4–12 weeks,
    leaving only your own collagen behind.
  • Cannula-based techniques significantly
    reduce the risk of vascular injury.
Treatment effects
Minimizes the risk of serious complications
such as vascular occlusion, has almost no foreign-body reaction, and carries an extremely
low risk of allergy. Additionally, there is no
need for hyaluronidase dissolution,
as would be required with fillers.

How is UltraCol 200 different from other treatments?

Based on my many years of experience, UltraCol 200 is especially suitable for those who want natural-looking improvement. After performing countless treatments over the past 20 years, I’ve realized that what patients appreciate most is “looking better without looking like they had something done.”


Natural volume and safety
at the same time
It induces your own collagen production, creating natural volume while offering high safety. 

Limitations

Because the effects develop gradually, it may not be ideal for those who need instant volume correction.
 Juvelook Volume (PDLLA + HA) : Provides faster volume enhancement along with collagen stimulation.
Standard fillers (HA) : Provide immediate volume correction and can be dissolved with hyaluronidase if needed.


Differences Compared to Other Treatments


Juvelook Volume 
Main
ingredients		PDLLA (Poly-D,L-lactic acid), HA (Hyaluronic Acid)
Particle size Larger particles than
Juvelook Skin
How Each
Technology
Works		Induces self-collagen
production
Recommended areas 
Cheeks / cheekbones /
jawline / temples
Onset of
results
Gradual effect
over 4–6 months
Duration 
12–18 months
Technique
Micro-cannula
Advantages
Excellent biocompatibility with no need for allergy
testing / Natural volume
with minimal bruising and
swelling
Disadvantages
Possibility of nodule
formation, and hydration
process is important / Takes time for effects to appear
Recommended number
of sessions 		3 sessions at1-month
intervals
 UltraCol 200
Main
ingredients		PDO (Polydioxanone)
Particle size50~110㎛
How Each
Technology
Works		Induces self-collagen
production
Recommended areas 
Under-eye / nasolabial
folds / jawline / forehead
Onset of
results
Full effect after
4–12 weeks
Duration 
1session: 3–4 months /
2~3 session: 1–1.5 years
Technique 
Cannula
Advantages
Natural volume enhancement / High safety with
minimal risk of side
effects / Minimal pain and immediate return to daily activities
Disadvantages
Takes time for effects to
appear / Multiple
sessions recommended
Recommended number
of sessions		3 sessions at 1-month
intervals
Standard HA Filler
Main
ingredients		Hyaluronic Acid (HA)
Particle sizeVaries
How Each
Technology
Works		Provides immediate
volume
Recommended areas 
Various areas such as
forehead / nose /
lips / chin
Onset of
results 
Immediate results
Duration 
6–12 months (standard) /
18–24 months (Voluma)
Technique 
Needle or cannula
Advantages
Immediate effect / Precise volume adjustment in
desired areas / Can be
dissolved with
hyaluronidase if needed
Disadvantages 
Possible foreign-body
sensation and unnatural
swelling /
Rare complications such
as vascular occlusion
Recommended
 number
of sessions 		1Effective
with a single session
mobile background
Highly recommended for  these individuals 

UltraCol 200 is recommended for the following people.

01

Those who are
concerned about
under-eye hollowness or dark circles

02

Those who worry
about deep wrinkles
such as nasolabial folds or around the mouth

03

Those who want natural volume without the artificial look of fillers

04

Those who want to
experience firmness

rising from

within the skin

05

Those who were worried about the side
effects of filler procedures

 One of my patients said, “After entering my 40s,
I felt depressed every time I looked in the mirror because of my sagging cheeks,”
but 3 months after UltraCol 200 treatment,
she said, “I look forward to seeing myself
in the mirror every morning.”
Seeing this kind of change is the most rewarding moment for me as a doctor. 

 UltraCol 200 
Individualized solutions for 3 different types

Before going into a detailed explanation of UltraCol,
let’s first discuss the treatment methods and effects of UltraCol 200 for each case type.

Case 01


For those concerned about
under-eye hollowness and dark circles


Treatment method
  • Using a blunt cannula (rounded tip), the under-eye area is approached gently, and the “micro-droplet” technique is used to inject very small amounts across multiple points.
  • This minimizes the risk of vascular injury and significantly reduces swelling or bruising. Typically, 2 sessions at 2–3 week intervals are ideal.
How Each Technology Works
  • The under-eye area has extremely thin and delicate skin.
  • The micro PDO spheres in UltraCol 200 settle in this area and precisely stimulate collagen production.
  • It also improves microcirculation, helping reduce pigmentation and capillary translucency — the major causes of dark circles.


Treatment effects


Strengthens support in the under-eye area to improve hollowness and
enhances microvascular circulation to reduce dark circles.
It also thickens the dermal layer, masking visible blood vessels and softening the overall
expression around the eyes with a natural filling effect.

Case 02


For those who want
natural volume in hollow areas


Treatment method
  • The “dual layering” technique is used to inject different densities into the deep and mid layers.
  • Focus is placed on areas that need volume, such as the temples, mid-cheek area, and infrazygomatic region.
  • For full-volume restoration, 3 sessions at 1-month intervals are recommended.
How Each Technology Works
  • UltraCol 200 does not create instant volume — it builds your own natural volume from within.
  • PDO micro-spheres stimulate gradual collagen production in the deeper dermis, creating volume that forms internally.
  • This is similar to "bread dough rising naturally."


Treatment effects


Creates natural volume without excessive swelling, improves facial contour balance,
and restores sunken cheeks or temples naturally.
The results become even more natural and refined over time.

Case 03


For those hesitant about fillers
due to safety concerns


Treatment method
  • A blunt-tipped cannula is used to safely approach the area and inject only into the precise intended layer while avoiding vascular-dense regions.
How Each Technology Works
  • The PDO component of UltraCol 200 is a proven material that has been used for over 30 years as medical sutures.
  • It is a fully biodegradable substance that completely dissolves within 4–12 weeks, leaving only your own collagen behind.
  • Cannula-based techniques significantly reduce the risk of vascular injury.


Treatment effects


Minimizes the risk of serious complications such as vascular occlusion,
has almost no foreign-body reaction, and carries an extremely low risk of allergy.
Additionally, there is no need for hyaluronidase dissolution, as would be required with fillers.

How is UltraCol 200 different
from other treatments?

Based on my many years of experience, UltraCol 200 is especially suitable for those who want natural-looking improvement.

After performing countless treatments over the past 20 years, I’ve realized that what patients appreciate most is “looking better without looking like they had something done.”


Natural volume and safety at the same time

It induces your own collagen production, creating natural volume while offering high safety.



Limitations


Because the effects develop gradually, it may not be ideal for those who need instant volume correction.
Juvelook Volume (PDLLA + HA) : Provides faster volume enhancement along with collagen stimulation.
Standard fillers (HA) : Provide immediate volume correction and can be dissolved with hyaluronidase if needed.

Differences Compared to Other Treatments




Juvelook Volume 
UltraCol 200
Standard HA Filler
Main ingredients
PDLLA (Poly-D,L-lactic acid), HA (Hyaluronic Acid)
PDO (Polydioxanone)
Hyaluronic Acid (HA)
Particle size
Larger particles than Juvelook Skin
50~110㎛
 Varies
How Each Technology Works
Induces self-collagen production
Induces self-collagen production
Provides immediate volume
Recommended areas 
Cheeks / cheekbones / jawline / temples
Under-eye / nasolabial folds / jawline / forehead
Various areas such as forehead / nose / lips / chin
Onset of results 
Gradual effect over 4–6 months 
Full effect after 4–12 weeks 
Immediate results
Duration 
12–18 months
1session: 3–4 months / 2~3 session: 1–1.5 years
6–12 months (standard) / 18–24 months (Voluma)
Technique 
Micro-cannula
Cannula
Needle or cannula
Advantages
Excellent biocompatibility with no need for allergy testing / Natural volume with minimal bruising and swelling
Natural volume enhancement / High safety with minimal risk of side effects / Minimal pain and immediate return to daily activities
Immediate effect / Precise volume adjustment in desired areas / Can be dissolved with hyaluronidase if needed
Disadvantages
Possibility of nodule formation, and hydration process is important / Takes time for effects to appear
Takes time for effects to appear / Multiple sessions recommended
Possible foreign-body sensation and unnatural swelling / Rare complications such as vascular occlusion
Recommended number of sessions 
3 sessions at 1-month intervals
3 sessions at 1-month intervals
1Effective with a single session
mobile background

01

Those who are concerned about under-eye hollowness or
dark circles

02

Those who worry about deep wrinkles such as nasolabial folds or around the mouth

03

Those who want natural volume without the artificial look of fillers

04

Those who want to experience firmness rising from within
the skin

05

Those who were worried about the side effects of filler procedures

How is the procedure performed ?

UltraCol 200 treatment is actually simpler than most people think. The entire procedure usually takes about 30–40 minutes, and you can return to daily activities immediately after. Many of my patients even come during their lunch break, get the treatment, and go straight back to work.

    STEP 1    

Consultation
and diagnosis

Through a consultation, we identify your skin condition and the areas you want to improve..

      STEP 2    

Application of
numbing cream

Numbing cream is applied to minimize discomfort

    STEP 3    

UltraCol 200
procedure 

Using a cannula (blunt needle), UltraCol 200 is injected precisely into the correct skin layer.

      STEP 4    

Final 
care

A cooling pack is applied after the procedure to finish the treatment.

How is the procedure performed ?

UltraCol 200 treatment is actually simpler than most people think.

The entire procedure usually takes about 30–40 minutes, and you can return to daily activities immediately after.

Many of my patients even come during their lunch break, get the treatment, and go straight back to work.







STEP 1

Consultation and diagnosis

Through a consultation, we identify your skin condition and the areas you want to improve.

STEP 2

Application of numbing cream

Numbing cream is applied to minimize discomfort

STEP 3

UltraCol 200 procedure 

Using a cannula (blunt needle), UltraCol 200 is injected precisely into the correct skin layer.

STEP 4

Final care

A cooling pack is applied after the procedure to finish the treatment.

How long do the results last?

Duration depending on number of sessions and interval

This can vary depending on your skin condition, lifestyle habits, age, etc.

Some of my patients maintain the results even longer with consistent home care.

How long do the results last?

 Duration depending on number of sessions and interval

This can vary depending on your skin condition, lifestyle habits, age, etc. Some of my patients maintain the results even longer with consistent home care.

1
With one session

Results last about 3–4 months.

2
After completing the recommended
3 sessions (at 1-month intervals)

- Results last about 1 year to up to 1 year and 6 months.

How should I take care of my skin after the procedure ?

Following these guidelines will help you achieve better results.

Avoid excessive exercise
Please avoid strenuous workouts on the day of the procedure.
Avoid high-heat environments
 Avoid saunas, hot spas, and swimming pools for 48 hours. 
Minimize irritation
Do not massage or rub the treated area.
Boost collagen
with protein intake 
A protein-rich diet helps with collagen production
Hydration and sun protectionstron
Adequate hydration and proper sunscreen use are essential.
mobile background
How should I take care of
my skin after the procedure ?

Following these guidelines will help you achieve better results.

Avoid excessive exercise : Please avoid strenuous workouts on the day of the procedure..
Avoid high-heat environments : Avoid saunas, hot spas, and swimming pools for 48 hours.
Minimize irritation : Do not massage or rub the treated area.
Boost collagen with protein intake : A protein-rich diet helps with collagen production
Hydration and sun protection : Adequate hydration and proper sunscreen use are essential.

 Conclusion

In Closing

Having worked as a dermatologist for 20 years, I have experienced many different procedures, but UltraCol 200 stands out for its natural results and safety profile. Some patients prefer the immediate effects of fillers, while others are comfortable waiting for gradual, natural-looking improvement. Choosing the treatment that best matches your skin condition and goals is what matters most.


If you have any questions, feel free to leave a comment anytime. I’ll continue to accompany you on your journey toward healthy, beautiful skin.

Supporting Clinical Research

The effectiveness of UltraColl 200 has been validated through multiple clinical studies. Recent findings show that after the injection of PDO microspheres, collagen production in the skin significantly increases, leading to improved skin elasticity and volume.

According to a 2023 study published in the Korean Journal of Dermatology, skin elasticity increased by an average of 27% after UltraColl treatment, and 92% of participants reported satisfactory results.

  1. Kim JH, Park JY, Han KH, et al. “Clinical efficacy of PDO micro-sphere injections for effective collagen regeneration.” Korean Journal of Dermatology. 2023;61(2):78–86.
  2. Lee SY, Choi JH, Kim WS. “Effect of PDO-based collagen boosters on facial volume: A 6-month follow-up study.” Korean Journal of Dermatology. 2022;28(3):112–119.
  3. Park SM, Lee JH, et al. “Correlation between PDO particle size and collagen production.” Asia-Pacific Journal of Dermatology Research. 2023;45(4):201–210.
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Operating Hours

 Tel. +82 2-6952-1234
Weekdays 
11:00 am ~ 8:30 pm 🌙
Saturday 
10:00 am ~ 4:30 pm 
(No lunch break)
Lunch Break
1:30 pm ~ 2:30 pm

Address
7F, Kate Clinic, 148 Yanghwa-ro, Mapo-gu, Seoul, Republic of Korea

   

Kate Clinic
 Business Registration Number: 525-36-00662 
 Representative : Lee Won-sang   |   E-mail : kateclinic@naver.com
Terms of Use   |   Privacy Policy

 ⓒKATE CLINIC. All Rights Reserved

 Operating Hours

 Tel. +82 2-6952-1234
Weekdays11:00 am - 8:30 pm 🌙
Saturday10:00 am - 4:30 pm (No lunch break)
Lunch Break1:30 pm – 2:30 pm

Address   7F, Kate Clinic, 148 Yanghwa-ro, Mapo-gu, Seoul, Republic of Korea

   

Kate Clinic   |   Business Registration Number : 525-36-00662   |   Representative: Lee Won-sang   |   E-mail : kateclinic@naver.com

Terms of Use   |   Privacy Policy    |   ⓒKATE CLINIC. All Rights Reserved